Thiomycalolides:  New Cytotoxic Trisoxazole-Containing Macrolides Isolated from a Marine Sponge Mycale sp.

Journal of Natural Products
1998.0

Abstract

Two new cytotoxic trisoxazole macrolides, thiomycalolides A (2) and B (3), have been isolated from a marine sponge Mycale sp. The structures were determined to be glutathione adducts of mycalolides A and B by interpretation of spectral data and chemical transformation. Thiomycalolides A and B are highly cytotoxic against P388 murine leukemia cells.

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