Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from Aspergillus niger Identified by Genome Mining

ChemBioChem
2014.0

Abstract

Induced production of tetronate derivatives: We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcription activator (caaR). As a result, the transformant expressing caaR produces three acyltetronate derivatives: carlosic acid (1), agglomerin F (2), and carlosic acid methyl ester (3).

Knowledge Graph

Similar Paper