Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers

Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272 Engineering the <i>aveC</i> gene to enhance the ratio of doramectin to its CHC‐B2 analogue produced in <i>Streptomyces avermitilis</i> Production of doramectin by rational engineering of the avermectin biosynthetic pathway Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226