Literature

Abstract

Activity-guided fractionation of Erythrophleum succirubrum for TRAIL resistance-overcoming activity led to the isolation of four new cassaine diterpenoid dimers, named erythrophlesins A–D (1–4). Their structures were elucidated by spectral data to show that they have an unsymmetrical dimeric structure through an ester bond between two cassaine diterpenoids. These new compounds were revealed to have a significant reversal effect on TRAIL resistance in human gastric adenocarcinoma (AGS) cells.

DOI： 10.1016/J.TETLET.2009.05.113

Cassaine diterpenoid dimers isolated from Erythrophleum succirubrum with TRAIL-resistance overcoming activity

Tetrahedron Letters 2009.0

Cytotoxic cassaine diterpenoid–diterpenoid amide dimers and diterpenoid amides from the leaves of Erythrophleum fordii

Phytochemistry 2010.0

New Cassaine Diterpenoid Amides with Cytotoxic Activities from the Bark of<i>Erythrophleum fordii</i>

Planta Medica 2006.0

Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of Erythrophleum fordii

Bioorganic & Medicinal Chemistry Letters 2017.0

New diterpenoids and the bioactivity of Erythrophleum fordii

Bioorganic & Medicinal Chemistry 2008.0

Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect