Two new securinega-type alkaloids, isobubbialine and epibubbialine, were isolated from the leaves of Phyllanthus amarus, as well as the three known alkaloids, phyllanthine, securinine and norsecurinine. The structures of the unknown compounds were determined by means of UV, IR, mass and NMR spectroscopy. Copyright (C) 1996 Elsevier Science Ltd