ChemInform Abstract: Antineoplastic Agent. Part 174. Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia.

ChemInform
1989.0

Abstract

A novel class of cytochalasans, penochalasins A, B and C, have been isolated from a strain of Penicillium sp. originally separated from the marine alga Enteromorpha intestinalis, and their stereostructures have been established on the basis of NMR spectral analyses and chemical transformations. Different conformations of penochalasin A in CDCl₃ and [²H₅]pyridine were determined by analysis of NMR data and molecular modelling. All the compounds exhibited potent cytotoxicity against cultured P388 cells.

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