Debromodispacamides B and D:  Isolation from the Marine Sponge Agelas mauritiana and Stereoselective Synthesis Using a Biomimetic Proline Route

Organic Letters
2008.0

Abstract

New debromopyrrole-2-aminoimidazolones, debromodispacamide B (1) and debromodispacamide D (2) were isolated from the sponge Agelas mauritiana, collected in the Solomon Islands. A biomimetic one-step reaction from pseudopeptides 5 and 13 in presence of air oxygen and guanidine gave the chiral form of the natural product stereoselectively.

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