Agelastatins C and D, New Pentacyclic Bromopyrroles from the Sponge Cymbastela sp., and Potent Arthropod Toxicity of (−)-Agelastatin A

Journal of Natural Products
1998.0

Abstract

Two new agelastatins, C (3) and D (4), along with the known compound (-)-agelastatin A (1), were isolated from the Indian Ocean sponge Cymbastela sp. The structures were determined by analysis of spectroscopic data and chemical correlation of 4 with a common derivative 5, also prepared from 1. Agelastatin A (1) exhibited potent activity against brine shrimp (LC50 1.7 ppm) in addition to insecticidal activity against larvae of beet army worm, Spodoptera exigua, and corn rootworm, Diabrotica undecimpunctata.

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