In our investigations of the chemistry and biological significance of the secondary metabolites of Bermudian tunicates, we found cytotoxicity (KB: IC50 = 12 μg/mL) and antimicrobial activity in the organic soluble extracts of Clavelina picta. From substantial collections (1-2 kg) made in the summer of 1984 and the spring of 1987, we have found the first quinolizidines from a tunicate and have evaluated the cytotoxicity of these novel compounds.