YM-215343, a Novel Antifungal Compound from Phoma sp. QN04621

The Journal of Antibiotics
2004.0

Abstract

Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2 to approximately 16 microg/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml.

DOI： 10.7164/ANTIBIOTICS.57.379

Knowledge Graph

Similar Paper

YM-215343, a Novel Antifungal Compound from Phoma sp. QN04621
The Journal of Antibiotics 2004.0
YM-193221, a Novel Antifungal Antibiotic Produced by Pseudallescheria ellipsoidea
The Journal of Antibiotics 2004.0
YM-47522, a Novel Antifungal Antibiotic Produced by Bacillus sp. I. Taxonomy, Fermentation, Isolation and Biological Properties.
The Journal of Antibiotics 1996.0
Yatakemycin, a Novel Antifungal Antibiotic Produced by Streptomyces sp. TP-A0356.
The Journal of Antibiotics 2003.0
Fumifungin, a new antifungal antibiotic from Aspergillus fumigatus Fresenius 1863.
The Journal of Antibiotics 1987.0
Structural Elucidation of YM-75518, A Novel Antifungal Antibiotic Isolated from Pseudomonas sp. Q38009
Tetrahedron Letters 1997.0
Total Synthesis of (+)‐Apiosporamide: Assignment of Relative and Absolute Configuration
Angewandte Chemie International Edition 2005.0
NK372135s, novel antifungal agents produced by Neosartoria fischeri.
The Journal of Antibiotics 1994.0
A new potent antifungal agent from Actinoplanes sp
Tetrahedron Letters 1998.0
Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina
Microbiology 1999.0