A concise enantiospecific synthesis of nuphar piperidine alkaloids: total synthesis of (–)-anhydronupharamine, (–)-nupharamine, (–)-nuphenine and (+)-3-epinupharamine

J. Chem. Soc., Chem. Commun.
2004.0

Abstract

Enantiospecific syntheses of (-)-anhydronupharamine, (-)-nupharamine, (-)-nuphenine, and (+)-3-epinupharamine are achieved starting from (-)-or (+)-carvone as chiral sources, in which a regioselective reductive fragmentation of the cyclopentane derivatives and an intramolecular aza-Wittig reaction were involved as key reactions.

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