Kottamides A−D:  Novel Bioactive Imidazolone-Containing Alkaloids from the New Zealand Ascidian Pycnoclavella kottae

The Journal of Organic Chemistry
2002.0

Abstract

Kottamides A-D (1-4), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian Pycnoclavella kottae and structurally characterized using 15N natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines.

Knowledge Graph

Similar Paper