<jats:p><jats:bold>Macrocyclic Spermidine Alkaloids from Maytenus mossambicensis (KLOTZSCH) BLAKELOCK</jats:bold><jats:p>In addition to celabenzine (<jats:bold>1</jats:bold>), three new macrocyclic spermidine alkaloids cyclocelabenzine (<jats:bold>2</jats:bold>), isocyclocelabenzine (<jats:bold>3</jats:bold>) and hydroxyisocyclocelabenzine (<jats:bold>4</jats:bold>) have been isolated from Maytenus mossambicensis (klotzsch) blakelock, <jats:italic>var. mossambicensis</jats:italic>. The three alkaloids show the 13‐membered lactam ring of celabenzine being linked to the benzoyl residue within the spermidine unit. Hydroxyisocyclocelabenzine (<jats:bold>4</jats:bold>) is the first known spermidine alkaloid with a hydroxy function at the macrocyclus. The structural elucidation was based mainly on spectroscopic methods, specially <jats:sup>1</jats:sup>H‐ and <jats:sup>13</jats:sup>C‐NMR. spectroscopy.