Macrocyclic Spermidine Alkaloids from Maytenus mossambicensis (KLOTZSCH) BLAKELOCK In addition to celabenzine (1), three new macrocyclic spermidine alkaloids cyclocelabenzine (2), isocyclocelabenzine (3) and hydroxyisocyclocelabenzine (4) have been isolated from Maytenus mossambicensis (klotzsch) blakelock, var. mossambicensis. The three alkaloids show the 13‐membered lactam ring of celabenzine being linked to the benzoyl residue within the spermidine unit. Hydroxyisocyclocelabenzine (4) is the first known spermidine alkaloid with a hydroxy function at the macrocyclus. The structural elucidation was based mainly on spectroscopic methods, specially 1H‐ and 13C‐NMR. spectroscopy. Copyright © 1982 Verlag GmbH & Co. KGaA, Weinheim