The stem bark of Zanthoxylum rubescens has furnished two new amides identified as N-methyl,N-(3,4 dimethoxyphenylethyl)-3',4'-dimethoxycinnamamide (rubemamide) and N-(3,4-dimethoxyphenylethyl)-3,4' dimethoxycinnamamide (rubemamin). Two other novel amides, N-methyl,N-(3,4-methylenedioxyphenylethyl)-3',4' methylenedioxycinnamamide (dioxamide) and N-(3,4-methylenedioxyphenylethyl)-3',4'-methylene dioxycinnamamide (dioxamin) were isolated from the roots. The structural assignments of these amides were confirmed by synthesis. Both the root and stem barks furnished the known aromatic amide, N-mathyl,N-(3,4-methylenedioxyphenylethyl) cinnamamide (zanthomamide). In addition, lupeol and arnottianamide were isolated and characterized from the roots.