Characterization of N‐Demethyllincosamide Methyltransferases LmbJ and CcbJ

Characterization of <i>N</i>‐Demethyllincosamide Methyltransferases LmbJ and CcbJ Deacetylation of mycothiol-derived ‘waste product’ triggers the last biosynthetic steps of lincosamide antibiotics STUDIES WITH STREPTOMYCES CAELESTIS. ANTIBIOTICS PRODUCED BY MUTANTS OF STREPTOMYCES CAELESTIS. I ANTIBIOTICS PRODUCED BY MUTANTS OF STREPTOMYCES CAELESTIS. I Celesticetin. V. Structure of celesticetin Co-overexpression of <i>lmbW</i> and <i>metK</i> led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of <i>Streptomyces lincolnensis</i> Characterization of the<i>N</i>-methyltransferases involved in the biosynthesis of toxoflavin, fervenulin and reumycin from<i>Streptomyces hiroshimensis</i>ATCC53615 ANTIBIOTICS PRODUCED BY MUTANTS OF STREPTOMYCES CAELESTIS Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline in Streptomyces aureofaciens