Trichodermone, a Spiro-cytochalasan with a Tetracyclic Nucleus (7/5/6/5) Skeleton from the Plant Endophytic Fungus Trichoderma gamsii

Journal of Natural Products
2014.0

Abstract

Trichodermone (1), the first spiro-cytochalasan with an unprecedented tetracyclic nucleus (7/5/6/5), together with its possible biosynthetic precursor aspochalasin D (2), was isolated from the endophytic fungus Trichoderma gamsii. Compound 2 displayed moderate inhibitory activity against HeLa cells with an IC50 value of 5.72 μM.

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