Turtschamide, a cytotoxic putrescine bisamide from Corydalis turtschaninovii

Tetrahedron Letters
2012.0

Abstract

A putrescine bisamide with a unique cyclic structure derived from L-tyrosine, turtschamide (1), was isolated from the tubers of Corydalis turtschaninovii. The structure of 1 was established by extensive spectroscopic study, and its absolute configuration was determined by a combination of NOE experiment and application of the Marfey's method. Turtschamide (1) exhibited cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 cells.

DOI： 10.1016/J.TETLET.2012.01.043

Knowledge Graph

Similar Paper

Turtschamide, a cytotoxic putrescine bisamide from Corydalis turtschaninovii
Tetrahedron Letters 2012.0
New Cytotoxic Tetrahydroprotoberberine-Aporphine Dimeric and Aporphine Alkaloids from<i>Corydalis turtschaninovii</i>
Planta Medica 2010.0
New Cytotoxic Tetrahydroprotoberberine-Aporphine Dimeric and Aporphine Alkaloids fromCorydalis turtschaninovii
Planta Medica 2010.0
Turbinamide, a New Selective Cytotoxic Agent from the Mediterranean Tunicate <i>Sidnyum turbinatum</i>
Organic Letters 2001.0
New Tetrahydroprotoberberine N-Oxide Alkaloids and Cytotoxic Constituents of Corydalis tashiroi
Planta Medica 1999.0
New Tetrahydroprotoberberine N-Oxide Alkaloids and Cytotoxic Constituents of Corydalis tashiroi
Planta Medica 1999.0
Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity
Bioorganic &amp; Medicinal Chemistry Letters 2010.0
Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity
Bioorganic &amp; Medicinal Chemistry Letters 2010.0
Cytotoxic isoquinoline alkaloids from the aerial parts ofCorydalis incisa
Archives of Pharmacal Research 2007.0
Studien iiber die Alkaloide der Papaveraceen. XVIII. Die Alkaloide von Corydalis incisa (11). Uber die Struktur des Corydamins
Chemical and Pharmaceutical Bulletin 1973.0