Novel Alkaloids from the Sponge Batzella sp.: Inhibitors of HIV gp120-Human CD4 Binding

The Journal of Organic Chemistry
1995.0

Abstract

The Caribbean sponge Batzella sp. contains a number of guanidine alkaloids, two of which, batzelladines A (1) and B (2), inhibit the binding of HIVgp-120 to CD4 and are therefore potential inhibitors of HIV. In addition to the known metabolites ptilomycalin A (6), ptilocaulin (7), crambescin A (8), crambescidin 800 (9), and crambescidin 816 (10), Batzella sp. contains five new alkaloids, batzelladines A-E (1-5), the structures of which were elucidated by interpretation of spectral data and chemical degradation.

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