The sponge Batzella sp, from Jamaica contains four new alkaloids, batzelladines F-I(1-4), that induce the p56(lck)-CD4 dissociation. Batzelladines F-I were isolated using a bioassay-directed fractionation scheme and were identified by interpretation of spectroscopic data, Batzelladines F, G, and H + I were active in the p56(lck)-CD4 dissociation assay at micromolar concentrations.