A phytochemical investigation of the leaves of Aspidospermu quebracho-blunco (Apocynaceae) resulted in the isolation of rhazinilam, a new nonindole lactam alkaloid, in addition to the known bases, aspidospermine, quebrachidine, (-)pyrifolidine, and akuammidine. Aspidospermine and quebrachidine were the major leaf alkaloids. Akuammidine and (-)pyrifolidine were isolated from the leaves for the first time, and the isolation of the latter compound confirms its natural Occurrence in this plant.