Alkanna orientalis (L.) Boiss. (Boraginaceae) is endemic to the southern part of the Sinai peninsula. Little is reported on the flavonoids of the Boraginaceae. The flavonoids of A. orientalis were identified by pc, uv, and ms as: kaempferol-3-glucoside, kaempferol-3-rutinoside, quercetin-3-glucoside, quercetin-3 rutinoside, kaempferol-3,6-dimethyl ether, and small amounts of its 7-glucoside. Kaempferol-3,6 dimethyl ether represents the major flavonoid. The 7-glucoside of kaempferol3,6-dimethyl ether was first reported in Centartsea jaea (1) and later in Tetragonofheca ludoviciana (2). The chromatographic and uv data are in agreement with those reported in the literature for the 7-glucoside (1,2). The chromatographic, uv, and ms data of kaempferol 3,6dimethyl ether are also in agreement with those reported in the literature (1,3,4).