Antineoplastic Agents. 542. Isolation and Structure of Sesterstatin 6 from the Indian Ocean Sponge Hyrtios erecta

Journal of Natural Products
2005.0

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 x 10(-7)% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 microg/mL, GI50 1.8-8.9 x 10(-1) microg/mL) and proved to be the most inhibitory of the series.

Knowledge Graph

Similar Paper

Antineoplastic Agents. 542. Isolation and Structure of Sesterstatin 6 from the Indian Ocean Sponge <i>Hyrtios erecta</i>
Journal of Natural Products 2005.0
Antineoplastic Agents. 386. Isolation of Sesterstatins 1−3 from the Marine Sponge <i>Hyrtios </i><i>e</i><i>recta</i><sup>1†</sup>
Journal of Natural Products 1998.0
Antimycobacterial Scalarane-Based Sesterterpenes from the Red Sea Sponge <i>Hyrtios </i><i>e</i><i>recta</i>
Journal of Natural Products 2005.0
Three New Cytotoxic Sesterterpenes from the Marine Sponge <i>Hyrtios</i> cf. <i>erectus</i>
Journal of Natural Products 1996.0
Cytotoxic Scalarane Sesterterpenes from a Sponge, <i>Hyrtios</i> <i>erecta</i>
Journal of Natural Products 1998.0
Antineoplastic Agents. 485. Isolation and Structure of Cribrostatin 6, a Dark Blue Cancer Cell Growth Inhibitor from the Marine Sponge <i>Cribrochalina </i>sp.<sup>,1a</sup>
Journal of Natural Products 2003.0
Antineoplastic Agents. 485. Isolation and Structure of Cribrostatin 6, a Dark Blue Cancer Cell Growth Inhibitor from the Marine Sponge <i>Cribrochalina </i>sp.<sup>,1a</sup>
Journal of Natural Products 2003.0
Salmahyrtisol A, a Novel Cytotoxic Sesterterpene from the Red Sea Sponge <i>Hyrtios </i><i>e</i><i>recta</i>
Journal of Natural Products 2002.0
Antineoplastic Agents. 535. Isolation and Structure of Plakorstatins 1 and 2 from the Indo-Pacific Sponge <i>Plakortis nigra</i>
Journal of Natural Products 2004.0
Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge <i>Ircinia </i><i>r</i><i>amosa</i>
Journal of Medicinal Chemistry 2004.0