The seed of Virola sebifera contains besides the polyketide 1 - (2',6' - dihydroxyphenyl) - 11 phenylundecan - 1 - one, four neolignans: (2S, 3S, 4R) - 4 - hydroxy - 2,3 - dimethyl - 5,6 - methylenedioxy - 4 piperonyl - 1 - tetralone and its 2-epimer, as well as (2R, 3R, 4s) - 4 - hydroxy - 6,7 - dimethoxy - 2,3 - dimethyl - 4 - piperonyl - 1 - tetralone and its (2R, 3S, 4R) - dehydroxy analogue.