Seven rare and four known alkaloids have been isolated from two varieties of Tylophora indica. The new alkaloids include tyloindicines A-E, (+)- 14-hydroxyisotylocrebrine and 4,6-desdimethylisotylocrebrine. Tylophorine, 6-desmethyltylophorine, tylophorinidine and 5-hydroxy-O-methyltylophorinidine were the known alkaloids. Structural studies indicate that apart from tyloindicine B all alkaloids possess the dibenzo-[f, h] pyrrolo [ 1 2b] isoquinoline skeleton but differ in the number, nature and distribution of the oxygen-bearing substituents, in the presence or absence of C-13a or benzylic hydroxyls and an angular methyl function. Tyloindicine B possesses a cleaved substituted phenanthrene moiety nucleus and an angular methyl group on the indolizidine portion. © 1989.