Along with known digitoxigenin r+thevetoside and u-L-acofrioside, the corresponding glycosides of a Cnor-D-homocardenolide were isolated from the air-dried leaves of Theuetia neriifolia and their structures determined by spectral and chemical methods. Triosides of the C-nor-D-homo-cardenolide were obtained from the methanol extract of the fresh leaves.