<jats:p>From the leaves of <jats:italic>Strempeliopsis strempelioides</jats:italic> K. SCHUM. (<jats:italic>Apocynaceae</jats:italic>), an indigenous species from Cuba, the following alkaloids were isolated: (+)-Demethylaspidospermine, (-)-aspidosine, (+)-tubotaiwine, (-)-vallesine, (+)-condylocarpine and (+)-eburnanomine. From stem bark of the plant the following alkaloids were isolated: (-)-Aspidospermine, (+)-deacetylaspidospermine, (+)-vincadifformine, (_)-apparicine, (+)-tubotaiwine, (+)-condylocarpine and (+)-demethylaspidospermine. All the structures were proposed on the basis of spectral evidence and chemical reactions.