Sulphones derived from methylthiopropenoic acid amides from Glycosmis angustifolia

Phytochemistry
1994.0

Abstract

Seven new sulphones derived from methylthiopropenoic acid amides have been isolated as dominant components from the methanolic leaf extract of Glycosmis angustifolia collected in Sri Lanka. All derivatives contained substituted phenethylamine moieties with prenyloxy (dambullins) or geranyloxy groups (gerambullins) in the paraposition. Additional oxidation of the geranyl side chain leads to a diol (gerambullindiol) and to ketones (methylgerambullone and methylisogerambullone). The major component, methyldambullin, exhibited moderate antifungal activity.

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