The lipophilic leaf, stem and root extracts of Glycosmis trichanthera are characterized by distinct chemical profiles, containing sulphur-containing amides in the leaves, prenylated acridone alkaloids in the stem bark, and quinoline alkaloids together with a 3,7-diprenylated indole in the root bark. Two isomeric sulphones derived from methylhio-propenoic acid phenethylamides, named trichanthin-A and -B, and the 3,7-diprenylated indole proved to be new natural products. Structure elucidation of the new compounds is described by spectroscopic evidence. Bioautographic tests with Cladosporium herbarum showed only moderate antifungal activity for trichanthin-B and methylgerambullin. (C) 1998 Elsevier Science Ltd.All rights reserved.