New triterpenes from heinsia crinata

Tetrahedron
1989.0

Abstract

The perchloric acid hydrolysis of a mixture of samins from the root bark of HEINSIA CRJNATA yielded three major genins. Their structures were established on thebasis of IR, NMR and Mass Spectmmetry. Twoofthemwereshown to be new triterpenes of the cycloartene snd lsnostene type with a 27-carboxylic group linked to the amino function of 4-hydroxyisoleucine in its 7-la&one form. Beinsia crinata (Rubiaceae) is a wild plsnt widely used in folk African medicine againstgonorrhoea anddiarrhoea. The crude drug is also used as a sexual stimulsnt.1'2 Our chemical screening of the root bark of H. crinata indicated the presenceof saponins se major constituents of this drug. This paper describes the isolation of cNde saponins and the structure elucidation of three genins obtained by acid hydrolysis.

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