Verbenachalcone, a Novel Dimeric Dihydrochalcone with Potentiating Activity on Nerve Growth Factor-Action from Verbena littoralis

Journal of Natural Products
2001.0

Abstract

A novel dimeric dihydrochalcone, verbenachalcone (1), was isolated from the aerial parts of Verbena littoralis. Its structure was elucidated, on the basis of spectral data interpretation, as 4,2',4',2' ",4' "-pentahydroxy-3' '-methoxy-3-O-4' '-tetrahydrobichalcone. This compound caused a significant enhancement of nerve growth factor-mediated neurite outgrowth from PC12D cells.

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