Biosynthesis of vitamin B12: order of the later C-methylation steps

Journal of the Chemical Society, Chemical Communications
1985.0

Abstract

Pulse labeiling experiments with [methyl-13C]S-adenosylmethionine (SAM) had previously shown that during the biosynthesis of vitamin BI2, the fourth C-methylation site is C-17; new inverted pulse studies show that the remaining four SAM-derived methyl groups are introduced in the order 12, 1, 15,5.

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