Isolation and amino acid compositions of geographutoxin I and II from the marine snailConus geographus Linné

Experientia
1983.0

Abstract

The peptide toxins having inhibitory effects on the contractile response of the mouse diaphragm to direct stimulation, geographutoxin I and II, have been isolated from Conus geographus, and their amino acid compositions have been determined. S(+)-4,5-dihydrodiazepam was found to have higher binding affinity for human serum albumin than its antipode. The binding of 4-carbamoyl-4,5-dihydrodiazepam is weak and not stereoselective.

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