A new indole alkaloid, 19-O-ethylangustoline, as well as the known alkaloids angustoline, angustine, angustidine and nauclefine were isolated from the stem bark of Sarcocephalus latifolius (Smith) Bruce and characterised by spectral methods. The absolute stereochemistry at C-19 of angustoline and 19-O-ethylangustoline was determined by Horeau's method and optical rotatory dispersion.