Total Synthesis of (±)‐20‐epi‐Kopsiyunnanine K: A Domino and Stereocontrolled Approach

Chemistry – An Asian Journal
2024.0

Abstract

A one-pot route to a novel azepane-fused tetrahydro-beta-carboline framework from tryptyl-4-pentenamide derivatives has been developed, featuring the Rh-catalyzed hydroformylation double cyclization. Subsequent alkylation in the tetracyclic system proceeded stereoselectively to form a quaternary carbon. The synthesis of (+/-)-20-epi-kopsiyunnanine K was accomplished through the strategy.

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