Direct, four-step synthetic pathway to iheyamine A and several analogues

Organic & Biomolecular Chemistry
2022.0

Abstract

A novel synthetic route toward the pentacyclic azepinobisindole alkaloid iheyamine A and its several analogues has been developed in four steps from commercially available isatins and tryptamines. This crucial transformation involves the Bischler-Napieralski cyclization to deliver the characteristic seven-membered framework. Then the ester intermediate undergoes a hydrolyzation-decarboxylation-dehydrogenation cascade to yield the final product. © 2022 The Royal Society of Chemistry.

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