Seven undescribed 3,4-secolanostane triterpenoids, daldiconoids A-G (1-7), 1 - 7 ), were isolated from the fruiting bodies of Daldinia concentrica. . Daldiconoid A (1) 1 ) was a highly modified 4,6,28,29-tetranorlanostane triterpenoid alkaloid featuring an unusual delta-lactam fused with a flanking cyclopentenone architecture. Their structures were determined by spectroscopic data, NMR calculations coupled with the DP4+ + analysis, X-ray single-crystal diffraction, and chemical transformation. The plausible biosynthetic pathway for 1 was proposed. Compounds 1 , 2 , and 4 - 6 inhibited the expressions of IL-1 beta, beta , IL-6, and TNF-alpha alpha in lipopolysaccharide stimulated RAW264.7 cells at a concentration of 10 mu M. Mechanistically, Compounds 1 and 2 blocked the JAK2/STAT3 signaling pathway induced by lipopolysaccharide.