Total Synthesis of Nagelamide W

The Journal of Organic Chemistry
2023.0

Abstract

Herein, we report the total synthesis of nagelamide W(1), a pyrrole imidazole alkaloid of the nagelamide familyisolatedin 2013. The key approach in this work involves the construction ofthe 2-aminoimidazoline core of nagelamide W from alkene 6 througha cyanamide bromide intermediate. The synthesis of nagelamide W wasaccomplished with an overall yield of 6.0%.

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