Nagelamides U–W, bromopyrrole alkaloids from a marine sponge Agelas sp.

Tetrahedron Letters
2013.0

Abstract

Three new structurally unique bromopyrrole alkaloids, nagelamides U-W (1-3), were isolated from a marine sponge Agelas sp. Nagelamides U (1) and V (2) possess a gamma-lactam ring with an N-ethanesulfonic acid and guanidino moieties, while nagelamide W (3) has two aminoimidazole moieties in the molecule. The structures of 1-3 were elucidated on the basis of spectroscopic data. Nagelamides U (1) and W (3) exhibited antimicrobial activity against Candida albicans. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2013.05.023

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