Synthesis of lysiformine, a marine-derived 3-hydroxypyridine alkaloid

Tetrahedron Letters
2023.0

Abstract

A synthesis of the bisindole alkaloid lysiformine is reported. The heterocyclic skeleton of the natural product was assembled from a kojic acid-derived pyridine using iterative Suzuki coupling and reductive alkylation reactions. The NMR spectroscopic data of the synthetic sample was in excellent agreement to the natural product, confirming that lysiformine is a rare example of a marine natural product harbouring a 3-hydroxypyridine.

DOI： 10.1016/j.tetlet.2023.154671

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