Copper(I)‐Catalyzed Cascade Cyclization to the Total Synthesis of Hexahydropyrroloindole Alkaloids: Flustramine B and Debromoflustramine B

ChemistrySelect
2021.0

Abstract

In this report, we have accomplished the total synthesis of two bioactive hexahydropyrroloindole (HPI) alkaloids bearing a C3a tetrasubstituted stereocenters substituted by isopentenyl. This route was based on Cu-catalyzed cascade arylation-alkylation sequence in one-pot as a key step, providing Flustramine B and Debromoflustramine B with 9 steps in 37.6 % and 31.1 % overall yields, respectively.

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