Total Synthesis and Determination of Structure of the Pyrrolizidine Alkaloid Curassanecine

Journal of Natural Products
1991.0

Abstract

The first total synthesis of curassanecine [1], a new bicyclic alkaloid recently isolated from Fleliotropium curassavicum, was realized in three steps from N-acetylpyrrolidine in 48% overall yield. Pulsed methods in 2D liquid phase nmr, in particular heteronuclear multiple bond correlation (HMBC) and correlation with a compound the structure of which was determined by X-ray crystallography, were used to confirm without ambiguity the structure and relative stereochemistry of this alkaloid. © 1991, American Chemical Society. All rights reserved.

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