Synthesis of Two Macrocyclic Fragments of Manadomanzamine Alkaloids

Chemistry Letters
2022.0

Abstract

The synthesis of two macrocyclic fragments in the manadomanzamine alkaloids based on a strategy using reductive nucleophilic addition to macrolactams is reported. The sequence through the Wittig coupling and macrolactamization gives quick access to both eleven-membered and ten-membered macrolactams. The iridium-catalyzed reductive Strecker reaction of the ten-membered macrolactam takes place via the corresponding unstable imine intermediate. © 2021 The Chemical Society of Japan.

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