Total Synthesis of (±)-Thebainone A by Intramolecular Nitrone Cycloaddition

Organic Letters
2020.0

Abstract

Using an intramolecular nitrone cycloaddition and a Heck cyclization as the crucial transformations, a total synthesis of the racemic morphine alkaloid thebainone A was accomplished in 22 steps commencing with isovanillin.

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