A flexible strategy for the synthesis of bifunctional 6′-(thio)-urea containing Cinchona alkaloid ammonium salts

Tetrahedron
2020.0

Abstract

A flexible and functional group tolerant synthesis route to access a structurally diverse collection of bifunctional 6'-(thio)-urea containing Cinchona alkaloid-based chiral quaternary ammonium salts has been developed. This route gives access to more than 25 different novel urea- and thiourea-containing ammonium salt derivatives, which were not accessible so far. (C) 2019 Elsevier Ltd. All rights reserved.

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