A New Trimeric Cinchona Alkaloid as a Chiral Phase-Transfer Catalyst for the Synthesis of Asymmetric α-Amino Acids

Synthesis
2005.0

Abstract

A new trimeric cinchona alkaloid, the quaternary ammonium salt, alpha,alpha',alpha-tris[O(9)-allylcinchonidinium-(4-methylp tenoxymethyl)]benzene trichloride, has been synthesized and used as an efficient phase-transfer catalyst in asymmetric alkylation of N-(diphenylmethylene)glycine tert-butyl ester with very good yield (up to 97%) and high enantioselectivity (up to 98%).

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