Bulbine natalensis Baker is a native succulent herb that belongs to the family Asphodelaceae, and is regarded as precious, highly valued, and extensively used throughout the continent for medicinal purposes and in treating male impotency due to the aphrodisiac and invigorating effect. This study reviews the status of B. natalensis ethnobotanical uses, biological and chemical properties. This review was conducted from April 2019 to February 2020 by applying the mixed-method review approach, and in the framework of a complete description of B. natalensis species, data on morphology, distribution, and economic importance were discussed. Pharmacological screening reported that B. natalensis possesses anti-inflammatory and broad-spectrum antimicrobial properties. The bulbous plant vapour contains substances such as tannins, anthraquinones, cardiac glycosides, saponins, and alkaloids. Scientific evaluations from various researchers have substantiated the use of B. natalensis in the enhancement of male sexual disorders, cure of wounds, rashes, itches, ringworm, diabetes, rheumatism, cracked lips and herpes, diarrhea, and paroxysms among other diseases. © 2020 Musara and Aladejana.