Stereoselective total synthesis of (S)- and (R)-nuciferine using benzyne chemistry

Tetrahedron
2020.0

Abstract

Total syntheses of (S)- and (R)-nuciferine were accomplished through approach involving diastereoselective reaction between a chiral dihydroisoquinoline enamide and 2-(trimethylsilyl)phenyl trifluoromethanesulfonate promoted by CsF, affording a separable mixture of diastereoisomers, which provided (S)- and (R)-nuciferine via simple and efficient transformations. © 2020 Elsevier Ltd

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