Stereoselective Synthesis of Diastereomeric Berberine Alkaloids, O-Methylcorytenchirine and Coralydine

HETEROCYCLES
2021.0

Abstract

Racemic total synthesis of diastereomeric berberine alkaloids, O-methylcorytenchirine and coralydine, was achieved from the common isoquinoline intermediate of norlaudanosine. The relative stereochemistry of C8-C14 was successfully constructed by favorable axial attack of nucleophiles to the iminium of dihydroprotoberberines. © 2021 The Japan Institute of Heterocyclic Chemistry

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