Enantioselective total syntheses of (−)-cephalotaxine and (−)-amathaspiramide F through a key Ir/Cu dual catalysis

Organic Chemistry Frontiers
2023.0

Abstract

A recently developed Ir/Cu dual catalysed allylation, which could efficiently provide excellent enantio- and diastereoselectivity in the construction of vicinal tertiary and N-substituted quaternary stereogenic centres in one step, is strategically utilised for the first time in the syntheses of two alkaloids—cephalotaxine and amathaspiramide F. © 2023 The Royal Society of Chemistry

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